Nastaran Ahmadi; Seyed Mostafa Seyed Hosseini; Fatemeh Rismanian Yazdi; Masoud Mirzaei; Faezeh Dehghani-Tafti; Seyed Mahmood Sadr Bafghi; Amir Houshang Mehrparvar
Volume 23, Issue 4 , 2021
Abstract
Abstract
Background: Dyslipidemia, a genetic and multifactorial disorder of lipoprotein metabolism, is defined by elevations in the levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride, or some combination thereof ...
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Abstract
Background: Dyslipidemia, a genetic and multifactorial disorder of lipoprotein metabolism, is defined by elevations in the levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride, or some combination thereof as well as lower levels of high-density lipoprotein (HDL) cholesterol.
Objectives: This study aimed to investigate the prevalence and predictors of dyslipidemia in children and adolescents in the Yazd Greater Area, Yazd, Iran.
Methods: This cross-sectional study was conducted as a part of the national project implemented in Yazd Greater Area, Yazd, Iran. The sampling was performed using a multi-stage cluster sampling method on three age groups of girls and boys, including 6-9, 10-14, and 15-18 years old. Out of the total 1,035 children and adolescents who initially participated in this study, only 784 participants remained until the end. Data collection was performed using lifestyle questionnaires including Kiddie-SADS-Present and Lifetime Version software.
Results: The rate of high triglyceride was estimated at 1.4% and 4.2% in 6-9 and 10-18 years old children and adolescents, respectively. Moreover, the prevalence of high cholesterol, LDL, and HDL were obtained at 3.2%, 3.2%, and 25.6%, respectively. The prevalence of dyslipidemia in the total population of children and adolescents was estimated at 64.6% and 57.3% in boys and girls, respectively (P=0.038) in terms of demographic variables. Gender and increase in body mass index (BMI) were significantly associated with dyslipidemia with OR=1.35; 95% CI: 1.01-1.81 and OR=13.781; 95% CI: 3.78- 46.43, respectively. However, after adjustment for other factors, only an increase in BMI was significantly associated with dyslipidemia (OR=16.08; 95% CI: 4.49-57.59).
Conclusion: Overweight and obese adolescents had a higher concentration of serum blood triglycerides, compared to their counterparts. Weight control, lifestyle, and diet modification are three ways to reduce lipid disorders in adolescents.
Mohammadtaghi Sarebanhassanabadi; Seyed Jalil Mirhosseini; Masoud Mirzaei; Seyedeh Mahdieh Namayandeh; Mohammad Hossein Soltani; Ali Pedarzadeh; Zahra Baramesipour; Reza Faraji; Amin Salehi-Abargouei
Volume 19, Issue 7 , July 2017, , Pages 1-10
Abstract
Background: Metabolic Syndrome (MetS) is rapidly growing in today’s world as an important predictor for type 2 diabetes and cardiovascular disease.Objectives: The present study aimed at assessing the incidence of MetS and the most powerful components as predictors of MetS in a cohort study in central ...
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Background: Metabolic Syndrome (MetS) is rapidly growing in today’s world as an important predictor for type 2 diabetes and cardiovascular disease.Objectives: The present study aimed at assessing the incidence of MetS and the most powerful components as predictors of MetS in a cohort study in central Iran.Methods: This cohort study was a follow-up of participants (n = 2000 and aged 20 to 74 years), who were selected using multistage random cluster sampling method from urban areas of Yazd, Iran, during year 2005 and repeated in 2015. Metabolic Syndrome was defined using a modified version of National cholesterol education program adult treatment panel III (NCEP III) definition. To assess hazard ratio of components of MetS for crude and adjusted values in two models, Cox proportional hazard regression was used.Results: Prevalence of MetS was 44.8% (n = 887) at baseline. Therefore, we followed subjects without MetS (n = 809) in 2015. After about 10 years, MetS was developed in 56.1% (n = 454) of subjects. Incidence of MetS in males and females was 56.1/1000 person-years and 58.7/1000 person-years, respectively. The analysis revealed that incidence of MetS significantly increased with age and higher level of socio-economic status and decreased with high level of education. In females and males the most powerful component for incidence of MetS was high fasting blood glucose (HR = 16.6, 95% CI: 1.91 - 22.82) and hypertriglyceridemia (HR = 1.64, 95% CI: 1.02 - 2.6), respectively.Conclusions: The current study showed a high incidence of MetS in males and females residing in central Iran. Furthermore, community-based interventions that reduce MetS in the population are needed.
